2022 Microbial Pathogenesis in Alzheimer’s Research Grant
The Microbial Pathogenesis in Alzheimer's Disease Grant provides funding to identify a potential microbial link to Alzheimer’s disease. All awards must be narrowly focused on elucidating the possible roles of infectious agents in the causation of Alzheimer's disease. The grant awards will support innovative research including basic, clinical, and/or non-traditional approaches. This includes proposals that span the breadth of the microbial world including bacteria, fungi, parasites, viruses, and microbial synergy among other possibilities.
Provide funding to identify a potential microbial link to Alzheimer’s disease. All awards must be narrowly focused on elucidating the possible roles of infectious agents in the causation of Alzheimer's disease. The awards will support innovative research including basic, clinical, and/or non-traditional approaches.
This funding is designed to accomplish the following objectives:
To obtain evidence that an infectious agent or microbial community is correlated to Alzheimer’s disease.
To promote novel research in the field of microbial triggers for Alzheimer’s disease.
2.24 million dollars in grant funding will be available through the 2022 grant period. Individual grants will range between $30,000 - $250,000. Grant amount varies dependent on the merits of the project.
Distribution of grants is as follows (but not limited to):
- Up to six $250,000 awards to established investigators (Assistant Professor to Professor) who have already launched/developed initial research. Past awardees are eligible to apply.
- Up to five $100,000 awards to senior/mid-career investigators (Assistant Professor to Professor) to obtain preliminary data to facilitate development of a research proposal for submission to the NIH and/or other institutions to continue their research. These grant awards are not meant to duplicate current work.
- Up to three $50,000 awards to current investigators (past awardees) who have demonstrated significant progress in initial research findings and are looking to further their research. The awardees are expected to submit a research update instead of a regular application.
- Up to three $30,000 awards to fellows/early-career investigators (includes Instructors, Assistant Professors, Senior trainees/Fellows) to obtain preliminary data to facilitate development of a research proposal to submit at the $100,000 level. These grants will ensure that creative ideas emerge from the science. These grant awards are not meant to duplicate current work.
Research must concentrate on identifying the role of an infectious agent(s) in Alzheimer’s disease.
Projects that concentrate on indirect nonspecific phenomena such as inflammation or protein plaques and tangles will not be considered.
This is a one-time grant award to obtain preliminary data to facilitate development of a research proposal for submission to the NIH or other foundations or institutions for further funding.
Grant awards should not duplicate currently funded work.
Research Proposal Narrative
Multiple investigators working on the project at the time of application are allowed but there may only be one PI. Submission of a research proposal is required. The narrative research proposal should be a maximum of four pages and the proposal should include the following:
Abstract (250 words maximum)
Introduction and Background
Procedures and Methods
Benefits or Significance of the Research
All illustrations, tables, and figures
In addition, the application should include:
A list of citations (no more than 25) that support the research proposal must be included with the proposal (not included in page limit).
Letter of support from the institution leadership verifying institutional support and resources for proposed research (one-page maximum).
Letter from Institution verifying faculty appointment, and eligibility of PI to apply for external funding. The Letter of Support and verification/eligibility to apply can be within the same letter.
PI’s biosketch (using NIH biosketch format)
Conflict of Interest (COI) disclosure(s). IDSA Foundation does not require a specific form, please use the form provided by your institution.
Budget and justification not to exceed two pages.
A detailed budget including expenditures for personnel (salary and fringe benefits), supplies, services (I.e., data analysis, genomic/microbiome sequencing costs, statistical support among others), animal care should be provided. Costs should be reasonable and consistent with the project proposal.
A detailed and justified budget proportionate to the scope of the project must be included with the application.
Budget should be limited to 2 pages.
Equipment and travel costs (except travel to IDWeek) are not allowed.
No indirect costs are provided to the Institution to which grants are awarded.
Total salary support for PI and Co-PI (if applicable) should not exceed $15,000 each (this includes fringe cost).
Application should be submitted as an Adobe PDF document along with a budget page in Excel format. Excel sheets should be converted to PDF and uploaded along with Justification. Budget and justification should not exceed two pages.
All applications must be submitted in standard American English.
All terms must be spelled out the first time the term is used and note the appropriate abbreviation in parentheses. The abbreviation may be used thereafter.
Paper Size, Page Layout and Font
Paper size, page layout, and font size refer to the format of the NIH Grant (https://tinyurl.com/y9k64fwl)
Use standard letter paper (8½ X 11”)
Minimum margins are one-half inch on top, bottom, left, and right for all pages.
Use a single column format like this document.
The following fonts are recommended at a size of 11 points or larger: Arial, Georgia, Helvetica, and Palatino Linotype.
Figures, Tables, Figure Legends, Footnotes/Endnotes, Photographs and Images
A smaller type is acceptable, but must be in black ink, readily legible.
Footnotes or endnotes are to be numbered consecutively.
All illustrations, tables, and images (maximum of six) must be imbedded directly within the application.
Save all document attachments with descriptive filenames of 50 characters or less (including spaces).
Use one space (not two or more) between words or characters and do not begin the filename with a space or include a space immediately before the .pdf extension.
Avoid the use of ampersand (&) since it requires special formatting (i.e., &).
Only complete applications received by the deadline will be reviewed.
The IDSA Foundation strongly encourages applications by women, people of color, under-represented populations and those who have experienced varied and non-traditional career trajectories.
The review process is as follows:
Staff will review the application for completeness and compliance with grant proposal guidelines detailed above.
Application materials will be distributed to the Research Review panel for preliminary scoring.
The Research Review panel will meet to discuss applications and make recommendations to the IDSA Foundation Board of Directors.
Final approval for funding will be made by the IDSA Foundation Board of Directors.
Applicants will be notified in writing of acceptance or rejection of the grant proposal.
The PI will sign a written agreement outlining the terms of the award. The start and end date of the twelve-month period will be included in the written agreement.
Any substantive changes to the original research plan or budget must be discussed with the IDSA Foundation and submitted in writing.
Awardees are required to submit a 2–3-page progress report at 6 and 12-months post award. Progress reports must contain a summary of significant findings and a financial accounting of grant expenditures.
Within 90 days of the final report submission (with date notification), all grant awardees will present final report findings in presentation form to the IDSA Foundation Board and grant funders.
All grant awardees must complete an annual post-award information form for 3 years following initial funding.
Awardees are strongly encouraged to submit a poster/presentation at IDWeek 2022
Attendance of IDWeek 2022
Travel costs for attending IDWeek 2022 will be covered
Publication of research is strongly encouraged.
All publications resulting from research using IDSA Foundation resources are required to cite the IDSA Foundation as a contributing source of support. When publishing articles related to this research, the following language should be used in its entirety:
Please visit www.IDSAFoundation.org/alz-research-grant/ for requirements and additional information regarding the 2022 Microbial Pathogenesis in Alzheimer’s Research Grant.
Note: The grant is offered to both Infectious Diseases Society of America (IDSA) and Non-IDSA members. These one-time grants are slated to identify potential microbial link to Alzheimer’s disease. Please review the Grant RFA for additional information.
For additional inquiries and questions, please email IDSA Foundation Director of Programs, Dr. Pearson-Fields